Latest research indicates that there is a number of key nutrients relating to resolving inflammation quicker and relieving pain effectively. Vitamin D, DHA and EPA are already known as beneficial nutrients for immunity, depression and mood disorders, osteoporosis, diabetes and weight loss, to name a few. Now we can also add them to treatment options for pain of any kind.
Vitamin D and pain
In the 2011 vitamin D study (1), which was a two-month, double-blind placebo-controlled randomised trial involving breast cancer patients, the researchers concluded that taking high levels of vitamin D for two months significantly reduced pain.
The women who received high-dose vitamin D had a dramatic reduction in pain, moreover they also didn’t lose any bone density, as vitamin D is well known to be necessary for calcium absorption thus impacting the bones.
According to the study, vitamin D helps chronic pain because it puts a lid on how much inflammation can take place. As such, vitamin D is the key nutrient that prevents the immune system responding excessively, leading to persisting inflammation = pain.
These findings have widespread implications to anyone with chronic pain as it is theoretically expected that receiving vitamin D, at some dose that is different for each individual, could help decrease inflammation and pain.
This would be a far better and less costly approach than typical anti-inflammatory drugs currently widely used to control pain. However, more studies are needed to prove this point conclusively.
The bottom line is while vitamin D was used to relieve pain in breast cancer patients, it has obvious implications for any sort of autoimmune pain, such as rheumatoid arthritis or pain in general.
Importantly, taking large amounts of supplemental vitamin D (e.g. in excess of 5,000 IU per day) needs supervised by an experienced practitioner, and individuals should have their blood tested before starting supplementation.
And then retested every three months during treatment to ensure their vitamin D levels do not elevate out of range (which leads to a different set of problems). The goal is to reach a vitamin D blood level that is toward the higher end of the range i.e. above 100 nmol/L (120-150 is considered to be a good level by naturopaths).
Healthy vitamin D levels
At present, in Australia the ‘normal’ level is over 50 nmol/L; however, many studies indicate, that ideal vitamin D levels to experience its benefits are between 100-120 nmol/L. Individuals with any type of chronic pain may therefore want to take high dose vitamin D to target a blood level closer to 120 nmol/L.
On average it takes 3-6 months of supplementation to achieve these levels. Read my comprehensive Vitamin D article for more details on sources and dosages.
Fish oils also have the ability to reduce pain and inflammation. It is known that the pain response involves interplay between immune cells and nerve cells. Many individuals experience exaggerated pain following an injury, surgery, or from other inflammatory causes.
Resolvins and pain
Pain signalling can overload nerve and immune function, tending to lock itself into place or prolong itself unnecessarily. New research (2) shows that essential fatty acids DHA and EPA promote a class of compounds called resolvins which restore nerve and immune cell function to normal in a more timely manner, thus getting rid of excess pain.
The researchers concluded, “Resolvins may offer novel therapeutic approaches for preventing and treating pain conditions associated with inflammation.”
So taking therapeutic doses of DHA and EPA represents another way to deal with pain. Resolvins also work synergistically with other nutrients that help manage repair and pain such as vitamin D, among others.
Summary
Of course vitamin D and DHA/EPA are not the only important nutrients relating to pain. However, they are the key, basic nutrients that play a role in how well the body handles inflammation and pain.
Supplementing with them, using therapeutic doses, is a far better strategy than taking anti-inflammatory drugs long-term, with their significant side effects and tissue damage effects.
Also, if the drugs are taken, these nutrients may help to use much lower doses or none at all.
Joanna Sochan
Holistic Health and Lifestyle Therapist
Natural and Lifestyle Therapies for Abundant Health and Wellbeing
References
(1) Antonella L. Rastelli, Marie E. Taylor, Feng Gao, Reina Armamento-Villareal, Shohreh Jamalabadi-Majidi, Nicola Napoli and Matthew J. Ellis. Vitamin D and aromatase inhibitor-induced musculoskeletal symptoms (AIMSS): a phase II, double-blind, placebo-controlled, randomized trial Breast Cancer Research and Treatment 2011 August Volume 129, Number 1, 107-116. Washington University School of Medicine in St. Louis.
(2) Ji RR, Xu ZZ, Strichartz G, Serhan CN. Emerging roles of resolvins in the resolution of inflammation and pain. Trends Neurosci 2011 September Pain Research Center, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women’s Hospital (BWH) and Harvard Medical School, Boston, MA 02115, USA.
(3) Wellness Resources (wellnessresources.com)
Additional resources
- Low vitamin D – what you need to know to achieve and maintain high levels
- Vitamin D deficiency: Do you know your current vitamin level? Check here if you are deficient
- How to drink enough water daily and improve your health – electrolytes
- Vitamin A: What you must know about this vital nutrient
- Online naturopathic consultations Australia
Disclaimer: The above material is for informational and/or educational purposes only. It should not be used to self-diagnose and it is not a substitute for a medical advice, diagnosis, treatment, prescription or recommendation. All viewers of this content, especially those taking prescription or over-the-counter medications, should not make any changes in their health regimen or diet before first consulting a doctor or other qualified health provider with any questions they may have regarding a medical condition or their particular circumstances.
Joanna Sochan is a Natural Therapist and founder of Naturimedica Holistic Health & Wellness. She has a passion for helping her clients transform their lives by becoming healthy and well naturally. Joanna is a fatigue, sleep and gut health expert helping tired, stressed or unwell individuals to regain their energy, sleep better and be happier, more relaxed and calm. Joanna practices in Sydney and Lake Macquarie, Australia and also conducts online consultations for clients Australia-wide. View full bio.

Hi Joanna,
I suffer from chronic pain which I am learning may be to do with inflammation and also depression and anxiety. I have read a lot of articles saying EPA and DHA can help with all these ailments but I’m struggling to find out a dosage guideline – specifically how much EPA and DHA to take daily. I have found a product which looks good and is specifically targeted at improving mood (Genuine Health +Joy) with a recommended daily dosage that gives you 2000mg of EPA but only 100mg of DHA – which seems very low – and I’m concerned I won’t be getting enough DHA from this dosage. Another brand I was recommended is Pure Encapsulations and their omega 3 essentials has a higher doses of DHA but less of the EPA than the Genuine health product – with a recommended daily dose of 600mg of EPA and 400mg of DHA. I could take more of the capsules to increase the EPA but this would also increase the cost as the packet will last less and I’m not sure I need any extra or if 600 EPA and 400 DHA would be a therapeutic dosage. I have no idea what the optimal therapeutic dosage should be or the ratio of EPA to DHA and am struggling to find an answer online. Do you have any recommendations on dosage and or specific brands? I’m aware lots of brands don’t offer the quality needed for the product to work but again it’s tricky to find out exactly what is needed so can only go by what the companies say their product will do – not ideal since they’re pretty bias! I have also read that triglyceride form may be better adsorbed than ethyl ester – Genuine health product that says it is specifically for mood improvement with the very high EPA but low DHA uses ethyl ester and Pure Encapsulations uses triglyceride which further confuses the situation. Lastly is liquid absorbed better than capsules? Would really appreciate your advice if you know the the answers to any of my questions – Goggle is a minefield!! Kind Regards, Adele